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Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus. Glasper ER, Llorens-Martin MV, Leuner B, Gould E, Trejo JL.
Hippocampus. 2009 Jul 14.
Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal.
Hernández-Rabaza V, Llorens-Martín M, Velázquez-Sánchez C, Ferragud A, Arcusa A, Gumus HG, Gómez-Pinedo U, Pérez-Villalba A, Roselló J, Trejo JL, Barcia JA, Canales JJ.
Neuroscience. 2008 Dec 16.
Hernández-Rabaza V, Hontecillas-Prieto L, Velázquez-Sánchez C, Ferragud A, Pérez-Villaba A, Arcusa A, Barcia JA, Trejo JL, Canales JJ.
The hippocampal dentate gyrus is essential for generating contextual memories of fear and drug-induced reward. Neurobiol Learn Mem.
2008 90(3):553-9.
Llorens-Martín M, Torres-Alemán I, Trejo JL.
Growth Factors as Mediators of Exercise Actions on the Brain. Neuromolecular Med.
2008 10(2):99-107.
Trejo JL, Llorens-Martín MV, Torres-Alemán I.
The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis.
Mol Cell Neurosci. 2008; 37(2): 402-411.
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Trejo JL, Piriz J, Llorens-Martin MV, Fernandez AM, Bolós M, LeRoith D, Nuñez A, Torres-Aleman I.
Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects.
Mol Psychiatry. 2007; 12(12):1118-28.
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LLorens-Martín M, Rueda N, Martínez-Cué C, Torres-Alemán I, Flórez J, Trejo JL
Both increases in immature dentate neuron number and decreases of immobility time in the torced swim test occurred in parallel alter environmental enrichment of mice. Neuroscience. 2007 Jun; 147:631-638..
Davila D, Piriz J, Trejo JL, Nunez A, Torres-Aleman I.
Insulin and insulin-like growth factor I signalling in neurons.
Front Biosci. 2007 May 1;12:3194-202.
Hernández-Rabaza V, Barcia JA, Llorens- Martín M, Trejo JL, Canales JJ.
Spared place and object-place learning but limited spatial working memory capacity in rats with selective lesions of the dentate gyrus.
Brain Res Bull. 2007 May 30;72(4-6):315-23.
Llorens-Martin M, Torres-Aleman I, Trejo JL.
Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons.
Hippocampus. 2006;16(5):480-90.
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Trejo JL, Carro E, Burks DJ.
Experimental models for understanding the role of insulin-like growth factor-I and its receptor during development.
Adv Exp Med Biol. 2005;567:27-53.
Torres-Alemán I, Carro EM, Trejo JL. Igf-1, Amiloid and Ad. Internacional Psychogeriatrics. 2005;17 Suppl. 2:48.
Carro E, Spuch C, Trejo JL, Antequera D, Torres-Aleman I.
Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci. 2005 Nov 23;25(47):10884-93.
Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I.
Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?
Neurobiol Aging. 2006 Nov;27(11):1618-31.
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Trejo JL*, Carro E*, Gerber A, Loetscher H, Torrado J, Metzger F, Torres-Aleman I.
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. Neurobiol Aging. 2006 Sep;27(9):1250-7.
Trejo JL, Carro E, Lopez-Lopez C, Torres-Aleman I.
Role of serum insulin-like growth factor I in mammalian brain aging.
Growth Horm IGF Res. 2004 Jun;14 Suppl A:S39-43.
Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I.
Role of insulin-like growth factor I signaling in neurodegenerative diseases.
J Mol Med. 2004 Mar;82(3):156-62.
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Perez-Martin M, Azcoitia I, Trejo JL, Sierra A, Garcia-Segura LM.
An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat.
Eur J Neurosci. 2003 Aug;18(4):923-30.
Carro E, Trejo JL, Nunez A, Torres-Aleman I.
Brain repair and neuroprotection by serum insulin-like growth factor I.
Mol Neurobiol. 2003 Apr;27(2):153-62.
Trejo JL, Carro E, Nunez A, Torres-Aleman I.
Sedentary life impairs self-reparative processes in the brain: the role of serum insulin-like growth factor-I.
Rev Neurosci. 2002;13(4):365-74.
Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I.
Serum insulin-like growth factor I regulates brain amyloid-beta levels.
Nat Med. 2002 Dec;8(12):1390-7.
Agudo M, Trejo JL, Lim F, Avila J, Torres-Aleman I, Diaz-Nido J, Wandosell F.
Highly efficient and specific gene transfer to Purkinje cells in vivo using a herpes simplex virus I amplicon.
Hum Gene Ther. 2002 Mar 20;13(5):665-74.
Garcia-Ovejero D, Trejo JL, Ciriza I, Walton KD, Garcia-Segura LM.
Space flight affects magnocellular supraoptic neurons of young prepuberal rats: transient and permanent effects.
Brain Res Dev Brain Res. 2001 Oct 24;130(2):191-205.
Carro E, Trejo JL, Busiguina S, Torres-Aleman I.
Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.
J Neurosci. 2001 Aug 1;21(15):5678-84.
Trejo JL*, Pons S*, Martinez-Morales JR, Marti E.
Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation.
Development. 2001 May;128(9):1481-92.
Trejo JL, Pons S.
Phosphatidylinositol-3-OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum.
J Neurobiol. 2001 Apr;47(1):39-50.
Trejo JL, Carro E, Torres-Aleman I.
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.
J Neurosci. 2001 Mar 1;21(5):1628-34.
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Trejo JL, Cuchillo I, Machin C, Rua C.
Maternal adrenalectomy at the early onset of gestation impairs the postnatal development of the rat hippocampal formation: effects on cell numbers and differentiation, connectivity and calbindin-D28k immunoreactivity.
J Neurosci Res. 2000 Dec 1;62(5):644-67.
Cardona-Gomez GP, Trejo JL, Fernandez AM, Garcia-Segura LM.
Estrogen receptors and insulin-like growth factor-I receptors mediate estrogen-dependent synaptic plasticity.
Neuroreport. 2000 Jun 5;11(8):1735-8.
Trejo JL, Rua C, Cuchillo I, Machin C.
Calbindin-D28k- and astroglial protein-immunoreactivities, and ultrastructural differentiation in the prenatal rat cerebral cortex and hippocampus are affected by maternal adrenalectomy.
Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):161-77.
Cuchillo I, Trejo JL, Machin C, Rua C.
Perinatal development of rat cerebellum from adrenalectomized mothers.
Int J Dev Biol. 1996;Suppl 1:263S-264S.
Trejo JL, Machin C, Arahuetes RM, Rua C.
Influence of maternal adrenalectomy and glucocorticoid administration on the development of rat cerebral cortex.
Anat Embryol (Berl). 1995 Jul;192(1):89-99.
Rua C, Trejo JL, Machin C, Arahuetes RM.
Effects of maternal adrenalectomy and glucocorticoid administration on the development of rat hippocampus.
J Brain Sci. 1995;36(4):473-83.
García-Segura LM, Cardona-Gómez GP, Trejo JL, Fernández-Galaz MC, Chowen JA (2000). Glial Cells Are Involved In Organizational And Activational Effects Of Sex Hormones In The Brain. En: Matsumoto, A. (Ed.): “Sexual Differentiation Of The Brain”, Crc Press, Boca Raton (Florida), Pp. 83-93.
Trejo JL, Carro EM, Burks DJ (2005). Experimental Models For Understanding The Role Of Igf-I And Its Receptor During Development. En: Varela, I., Y Chowen, J. (Eds.): “The Growth Hormone-Insulin-Like Growth Factor Axis During Development”, Kluwer Academic Publishers. (Pubmed Adv Exp Med Biol.; 567:27-53, 2005).
Carro EM, Trejo JL, Fernández S, Fernández AM, Torres-Alemán I. (2006). Igf-I And Neuroprotection. 209-215. En: Nyberg, F. (Ed.): “The Somatotrophic Axis In Brain Function”. Academic Press Elsevier (Amsterdam), 2006.